Enhanced cellular uptake and gene delivery of glioblastoma with deferoxamine-coated nanoparticle/plasmid DNA/branched polyethylenimine composites.

نویسندگان

  • Ken Cham-Fai Leung
  • Chun-Pong Chak
  • Siu-Fung Lee
  • Josie M Y Lai
  • Xiao-Ming Zhu
  • Yi-Xiang J Wang
  • Kathy W Y Sham
  • Christopher H K Cheng
چکیده

Ternary composite nanomaterials based on deferoxamine-coated superparamagnetic iron oxide nanoparticles (8-10 nm), circular plasmid DNA (~4 kb) with fluorescent/luminescent reporter group, and branched polyethylenimine (25 kDa, PDI = 2.5) were prepared and compared in terms of their efficiencies in transfecting brain tumor cells at low concentration.

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عنوان ژورنال:
  • Chemical communications

دوره 49 6  شماره 

صفحات  -

تاریخ انتشار 2013